Attenuation of Eph Receptor Kinase Activation in Cancer Cells by Coexpressed Ephrin Ligands
نویسنده
چکیده
................................................pag. 4 INTRODUCTION.........................................pag. 5 1RECEPTOR TYROSINE KINASES..........................pag. 5 1.1DOMAIN ORGANIZATION OF RECEPTOR TYROSINE KINASES 1.2RECEPTOR TYROSINE KINASE SIGNALING 1.3RECEPTOR TYROSINE KINASES AND CANCER 2EPH RECEPTOR SIGNALING AND EPHRINS.....pag. 11 2.1GENERAL FEATURES OF EPH RECEPTORS AND EPHRINS 2.2EPH RECEPTOR FORWARD SIGNALING 2.2.1Rho Family GTPases 2.2.2Ras Family GTPases
منابع مشابه
Attenuation of Eph Receptor Kinase Activation in Cancer Cells by Coexpressed Ephrin Ligands
The Eph receptor tyrosine kinases mediate juxtacrine signals by interacting "in trans" with ligands anchored to the surface of neighboring cells via a GPI-anchor (ephrin-As) or a transmembrane segment (ephrin-Bs), which leads to receptor clustering and increased kinase activity. Additionally, soluble forms of the ephrin-A ligands released from the cell surface by matrix metalloproteases can als...
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The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce signals from the cell exterior to the interior through ligand-induced activation of their kinase domain. However, the Eph receptors also have distinctive features. Instead of binding soluble ligands, they generally mediate contact-dependent cell-cell communication by interacting with surface-associated ligand...
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The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin-B1, ephrin-B2, and ephrin-B3 are ligands of the EPHB subgroup and are encoded by the EFNB1, EFNB2, and EFNB3 genes, respectively. We have shown previously that EPHB2 transcripts are expressed in six small cell lung carcinoma (SCLC) cell lines. In this study, we examine...
متن کاملEphrin-Mediated cis-Attenuation of Eph Receptor Signaling Is Essential for Spinal Motor Axon Guidance
Axon guidance receptors guide neuronal growth cones by binding in trans to axon guidance ligands in the developing nervous system. Some ligands are coexpressed in cis with their receptors, raising the question of the relative contribution of cis and trans interactions to axon guidance. Spinal motor axons use Eph receptors to select a limb trajectory in response to trans ephrins, while expressin...
متن کاملThe C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.
Interaction of the Eph family of receptor protein tyrosine kinases and their ligands, ephrin family members, induces bi-directional signaling via cell-cell contacts. High expression of B-type ephrin is associated with high invasion potential of tumors, however, the mechanism by which ephrin-B promotes cancer cell invasion is poorly understood. We show that interaction of ephrin-B1 with the Eph ...
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تاریخ انتشار 2014